This site offers a javascript implementation of gene-sets enrichments analysis (
MWW-GST) based on the
the Mann-Whitney test.
Two files are necessary to run the analysis: 1) a gene profile, and 2) a collection of gene-sets.
The gene-profile is a .txt file with a list of gene-symbols tab delimited with the corresponding intensity numeric value (eg. gene expression level; see
this file, for example).
The collection of gene-sets can be provided in
.gmt format (Gene Matrix Transposed file format),
see
this from Ma'ayan Laboratory, for example.
Others gene-sets collections in .gmt format can be obtained from
Molecular Signatures Database
and
Enricher.
Two file examples are provided here to tun the analysis:
the gene profile
and
the collection of the gene-sets.
Once the files has been uploaded the analysis can be started with the RUN button. Parameters, such as the alternative hypothesis and p-value and $logit2NES$ thresholds, can be set in the relative boxes. After few seconds results are shown below and can be retrieved also in
.csv, .tsv, or .html file formats.
A TITLE box allows you to integrate a caption in the displayed table, and in the .html file.